nt. Sci. Technol. J. Namibia, Adorka et al./ISTJN 2017, 9:49-60.
Matthias Adorka1∗, Motseng Letsa2, Mitonga Kabwebwe Honor´e3†, Kirk Allen4
1School of Pharmacy, University of Namibia, Windhoek, Namibia
2Faculty of Health Sciences, Department of Pharmacy, National university of Lesotho, Roma 1803School of Public Health, Faculty of Health Sciences, University of Namibia, Windhoek, Namibia4Faculty of Health & Medicine, Lancaster University, Lancaster, England
Background: Antihypertensive drugs may cause changes in blood glucose levels. The concurrent use of these medications with hypoglycaemic drugs in diabetic patients maycontribute to inadequate control of blood glucose levels.
Objectives: To describe the effects of prescribed antihypertensive agents on fasting blood glucose levels of non-insulin dependent diabetic patients on treatment with oral hypoglycaemic medications.
Method: Descriptive data on fasting blood glucose levels of diabetic patients on hy-poglycaemic and antihypertensive drug treatments were collected retrospectively for a six-month period. Data sources were medical records of patients attending diabeticclinics in five health centres in the Maseru Health Service Area of Lesotho. The records were categorised into two basic patient groups, namely, patient groups treated with only oral hypoglycaemic agents and patient groups treated with same agents concurrent with antihypertensive agents. Differences in the means of the initial and end of six-months period fasting blood glucose levels of patient treatment groups were determined and compared.
Results: Patients who received an antidiabetic drug regime concurrent with antihypertensive medication tended to show improved fasting blood glucose levels at six months, whereas patients receiving only antidiabetic drugs did not show improvement. Partly owing to the small sample size (178 patients), the differences were not statistically significant.
Conclusion: Hydrochlorothiazide prescribed singly or in combination with other antihypertensive drugs was implicated in increased blood glucose levels. Captopril showed better glycaemic control for patients on oral hypoglycaemicagents. Atenolol and nifedipine appeared not to have any effects on patients’ fasting blood glucose levels. A prospective case-control study would help clarify these findings in this study’s population.
Keywords: Diabetes, hypoglycaemic agents, antihypertensive agents, fasting bloodglucose levels, Lesotho